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M9640589.TXT
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1996-03-04
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Document 0589
DOCN M9640589
TI [Relationship between Epstein-Barr virus and lymphoproliferative
syndromes in patients without immunodeficiency]
DT 9604
AU Barranco M; Vidal J; Quintero L; Vives-Corrons JL; Jimenez de Anta MT;
Servicio de Microbiologia Hospital Clinico y Provincial,; Faeultad de
Medicina, Universidad de Barcelona.
SO Sangre (Barc). 1995 Oct;40(5):383-7. Unique Identifier : AIDSLINE
MED/96151807
AB PURPOSE: The relationship between Epstein-Barr virus (EBV) and
infectious mononucleosis, pharyngeal carcinoma and Burkitt's lymphoma is
well known. Further relationship seems to exist between EBV and the
lymphoproliferative syndromes appearing in immunodeficient subjects. The
present work is aimed to study the possible relationship between the
virus and the lymphoproliferative syndromes presented by people without
any apparent immunodeficiency. PATIENTS AND METHODS: The presence of
antibodies against different antigens of the virus was analysed.
Antibodies against the viral capsid antigen were studied along with
those against the early antigen and the viral core antigen in 55
patients with lymphoproliferative syndromes, of whom 38 had
non-Hodgkin's lymphoma and 17 had acute lymphoblastic leukaemia, and
none of them had immunodeficiency. RESULTS: Significantly higher
geometric means of the titres against capsid antigen and of the
prevalence of antibodies against early antigen were seen in the patients
with non-Hodgkin's lymphoma with respect to the control group. On the
contrary, patients with acute lymphoblastic leukaemia showed lower
immunologic response than the control group, although the difference was
not significant for any of the antibodies under study. CONCLUSIONS: The
higher immunologic response against EBV and its reactivation in
non-Hodgkin's lymphoma would suggest that such agent could play a role
favouring the onset of the disease, if not as a direct aetiological
factor.
DE Adolescence Adult Antigens, Viral/ANALYSIS/BLOOD English Abstract
Female Herpesviridae Infections/IMMUNOLOGY *Herpesvirus 4,
Human/IMMUNOLOGY/ISOLATION & PURIF Human Immunocompetence/IMMUNOLOGY
Leukemia, Lymphocytic, Acute/IMMUNOLOGY/*VIROLOGY Lymphoma,
Non-Hodgkin's/IMMUNOLOGY/*VIROLOGY Lymphoproliferative
Disorders/IMMUNOLOGY/*VIROLOGY Male Middle Age Tumor Virus
Infections/IMMUNOLOGY Viral Core Proteins/ANALYSIS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).